Preimplantation Genetic Testing (PGT): An Advanced Method for a Healthy Future
Preimplantation Genetic Testing (PGT) is an advanced technique used during IVF treatment to screen embryos for genetic abnormalities. At Clavis Fertility Center, we utilize the PGT method to ensure the genetic health of embryos, increasing the chances of a successful and healthy pregnancy.
What is PGT?
Genetic screenings are crucial for increasing the success of IVF treatment and maximizing the likelihood of a healthy pregnancy. At our laboratory, these screenings are conducted to comprehensively analyze the genetic structure of embryos, allowing for the early detection of potential genetic disorders. By enabling the transfer of healthy embryos, we significantly enhance the chances of couples having a healthy baby. In addition to ensuring a healthy pregnancy, gender selection for genetic screening purposes can also be performed.
Thanks to advancements in reproductive technology, genetic screenings of embryos before pregnancy have become increasingly common. This diagnostic method allows us to determine whether an embryo carries any chromosomal abnormalities or genetic disorders while still in the early stages of development. By doing so, it helps ensure healthier future generations. Additionally, PGT is a suitable method for couples carrying genetic mutations associated with cancer syndromes.
Another purpose of PGT is to identify potential genetic abnormalities in embryos for couples undergoing IVF due to infertility issues.
This process offers couples a higher chance of a healthy pregnancy and helps prevent the transmission of genetic diseases from one generation to another.
When is PGT Used?
PGT is commonly used in the following cases:
- Risk of Genetic Disorders: For couples with a family history of known genetic diseases.
- Recurrent Pregnancy Loss: For couples who have experienced multiple miscarriages.
- Advanced Maternal Age: When the mother-to-be is of advanced reproductive age.
- Repeated IVF Failures: For couples who have undergone unsuccessful IVF treatments in the past.
- Gender Selection: For couples who wish to choose a specific gender for medical or family planning reasons.
PGT (Preimplantation Genetic Testing) Methods
Preimplantation Genetic Testing (PGT) is a method that analyzes embryos for genetic abnormalities to increase the chances of a successful pregnancy. At Clavis Fertility Center, we use the latest technology and advanced methods for genetic screening. Here is a detailed overview of the different PGT methods:
1. NGS (Next Generation Sequencing)
Next-generation sequencing (NGS) is the most comprehensive genetic screening method currently available. It analyzes approximately 20,000 genes within embryos and screens all 23 chromosome pairs, including sex chromosomes.
- Quickly and effectively detects chromosomal-level genetic issues.
- Provides high accuracy and comprehensive results.
- Embryo biopsy is performed on day 5, and embryos are frozen.
- Results are available within 3-4 weeks, and the transfer is scheduled accordingly.
2. FISH (Fluorescence In Situ Hybridization)
FISH is a genetic screening method that provides quick results at a lower cost. Used since the 1990s, this technique involves staining the cell nucleus and examining it under a fluorescence microscope.
- Identifies common chromosomal abnormalities, including chromosomes 13, 15, 16, 17, 18, 21, 22, X, and Y.
- Due to its limited scope, it is often used primarily for gender selection.
- It is a practical and fast method, though it provides less information compared to newer techniques.
3. aCGH (Array Comparative Genomic Hybridization)
aCGH is a powerful genetic screening method that analyzes all 46 chromosomes and is particularly recommended for individuals with recurrent IVF failures.
- Helps prevent recurrent miscarriages and genetic disorders.
- Provides enhanced accuracy and reliable results.
- Biopsy is performed on day 5, and embryos are frozen before laboratory analysis.
- Results are obtained within 3-4 weeks, and the transfer is scheduled accordingly.
4. PCR (Polymerase Chain Reaction)
The PCR method is mainly used for screening single-gene disorders such as thalassemia or hemophilia. Cells obtained from the embryo are analyzed in a genetic laboratory to determine the risk of genetic diseases.
- Primarily used for detecting known mutations.
- Results are available within 24-36 hours, allowing for a transfer on day 5.
- More expensive compared to the FISH method.
5. Trophectoderm Biopsy (Day 5 Blastocyst Biopsy)
Trophectoderm biopsy is a method where cells are taken from embryos on day 5 and subjected to rapid genetic testing.
- Delivers quick results, with genetic analysis completed in as little as 2 hours.
- Embryo transfer can be conducted on the same day.
- Does not significantly alter the overall IVF process.
Why is PGT Important?
PGT methods play a critical role in maintaining genetic health and improving pregnancy success rates. At Clavis Fertility Center, our expert team works with you to determine the most suitable method for ensuring a healthy pregnancy.
Benefits of PGT
PGT offers numerous benefits to couples:
- Prevention of genetic diseases.
- Higher chances of successful pregnancy.
- Reduced risk of recurrent miscarriages.
- Increased likelihood of having a healthy baby.
- Accurate embryo selection based on genetic screening.
Is PGT Legal and Ethical?
In Cyprus, PGT is conducted in accordance with legal and ethical standards. At Clavis Fertility Center, we prioritize patient rights and ethical values, ensuring complete confidentiality throughout the process.
PGT at Clavis Fertility Center
Clavis Fertility Center utilizes the latest technologies and internationally recognized laboratory equipment to offer PGT services. Our expert team supports you at every stage, guiding you towards a successful and healthy pregnancy.
Contact Us
For more information about PGT and to plan your treatment, feel free to reach out to us. At Clavis Fertility Center, we are here to help you take the next step toward a healthy future.